Each opponent's maximum hand size is reduced by two.
If multiple effects modify a player's hand size, apply them in timestamp order. For example, if you put Cursed Rack (an artifact that sets a chosen player's maximum hand size to four) onto the battlefield choosing your opponent and then put Locust Miser onto the battlefield, your opponent will have a maximum hand size of two. However, if those permanents entered in the opposite order, your opponent's maximum hand size would be four.
